PhytophthoraV1, Main, Exploration, bibRecord, 000440

Novel 4-pyrazole carboxamide derivatives containing flexible chain motif: design, synthesis and antifungal activity.

Identifieur interne : 000440 ( Main/Exploration ); précédent : 000439; suivant : 000441

Novel 4-pyrazole carboxamide derivatives containing flexible chain motif: design, synthesis and antifungal activity.

Auteurs : Xing-Hai Liu [République populaire de Chine] ; Li Qiao [République populaire de Chine] ; Zhi-Wen Zhai [République populaire de Chine] ; Peng-Peng Cai [République populaire de Chine] ; Charles L. Cantrell [États-Unis] ; Chen-Xia Tan [République populaire de Chine] ; Jian-Quan Weng [République populaire de Chine] ; Liang Han [République populaire de Chine] ; Hong-Ke Wu [République populaire de Chine]

Source :

Pest management science [ 1526-4998 ] ; 2019.

RBID : pubmed:31050111

Descripteurs français

KwdFr :
- Ascomycota (effets des médicaments et des substances chimiques), Deuteromycota (effets des médicaments et des substances chimiques), Fongicides industriels (composition chimique), Fongicides industriels (pharmacologie), Fongicides industriels (synthèse chimique), Phytophthora infestans (effets des médicaments et des substances chimiques), Pyrazoles (composition chimique), Pyrazoles (pharmacologie), Pyrazoles (synthèse chimique), Relation structure-activité (MeSH).
MESH :
- composition chimique : Fongicides industriels, Pyrazoles.
- effets des médicaments et des substances chimiques : Ascomycota, Deuteromycota, Phytophthora infestans.
- pharmacologie : Fongicides industriels, Pyrazoles.
- synthèse chimique : Fongicides industriels, Pyrazoles.
- Relation structure-activité.

English descriptors

KwdEn :
- Ascomycota (drug effects), Fungicides, Industrial (chemical synthesis), Fungicides, Industrial (chemistry), Fungicides, Industrial (pharmacology), Mitosporic Fungi (drug effects), Phytophthora infestans (drug effects), Pyrazoles (chemical synthesis), Pyrazoles (chemistry), Pyrazoles (pharmacology), Structure-Activity Relationship (MeSH).
MESH :
- chemical , chemical synthesis : Fungicides, Industrial, Pyrazoles.
- chemical , chemistry : Fungicides, Industrial, Pyrazoles.
- drug effects : Ascomycota, Mitosporic Fungi, Phytophthora infestans.
- chemical , pharmacology : Fungicides, Industrial, Pyrazoles.
- Structure-Activity Relationship.

Abstract

BACKGROUND

In recent years, carboxamide fungicides, targeting succinate dehydrogenase (SDH), have shown highly efficient and broad spectrum fungicidal activity. Structure-activity relationship (SAR) results for these commercial fungicides show that the carboxamide group was a key active group. This is useful information for the discovery of new pyrazole carboxamide derivatives with fungicidal activity.

RESULTS

Twenty-seven novel pyrazole carboxamides were designed and synthesized. Their fungicidal activities against Gibberella zeae, Phytophthora infestans, Phytophthora capsici, Rhizoctonia solani, Alternaria solani, Botrytis cinerea, Fusarium oxysporum, Cercospora arachidicola, Sclerotinia sclerotiorum and Physalospora piricola were tested; derivatives possessed excellent inhibitory at 50 mg L

CONCLUSION

It is possible that pyrazole carboxamides, which exhibit good activity against Sclerotinia sclerotiorum, can be further optimized as a lead compounds of carboxamide fungicides. © 2019 Society of Chemical Industry.

DOI: 10.1002/ps.5463
PubMed: 31050111

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000485
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Le document en format XML

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<term>Fungicides, Industrial (chemical synthesis)</term>
<term>Fungicides, Industrial (chemistry)</term>
<term>Fungicides, Industrial (pharmacology)</term>
<term>Mitosporic Fungi (drug effects)</term>
<term>Phytophthora infestans (drug effects)</term>
<term>Pyrazoles (chemical synthesis)</term>
<term>Pyrazoles (chemistry)</term>
<term>Pyrazoles (pharmacology)</term>
<term>Structure-Activity Relationship (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Ascomycota (effets des médicaments et des substances chimiques)</term>
<term>Deuteromycota (effets des médicaments et des substances chimiques)</term>
<term>Fongicides industriels (composition chimique)</term>
<term>Fongicides industriels (pharmacologie)</term>
<term>Fongicides industriels (synthèse chimique)</term>
<term>Phytophthora infestans (effets des médicaments et des substances chimiques)</term>
<term>Pyrazoles (composition chimique)</term>
<term>Pyrazoles (pharmacologie)</term>
<term>Pyrazoles (synthèse chimique)</term>
<term>Relation structure-activité (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Fungicides, Industrial</term>
<term>Pyrazoles</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Fungicides, Industrial</term>
<term>Pyrazoles</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Fongicides industriels</term>
<term>Pyrazoles</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Ascomycota</term>
<term>Mitosporic Fungi</term>
<term>Phytophthora infestans</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Ascomycota</term>
<term>Deuteromycota</term>
<term>Phytophthora infestans</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Fongicides industriels</term>
<term>Pyrazoles</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Fungicides, Industrial</term>
<term>Pyrazoles</term>
</keywords>
<keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Fongicides industriels</term>
<term>Pyrazoles</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Structure-Activity Relationship</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Relation structure-activité</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>In recent years, carboxamide fungicides, targeting succinate dehydrogenase (SDH), have shown highly efficient and broad spectrum fungicidal activity. Structure-activity relationship (SAR) results for these commercial fungicides show that the carboxamide group was a key active group. This is useful information for the discovery of new pyrazole carboxamide derivatives with fungicidal activity.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Twenty-seven novel pyrazole carboxamides were designed and synthesized. Their fungicidal activities against Gibberella zeae, Phytophthora infestans, Phytophthora capsici, Rhizoctonia solani, Alternaria solani, Botrytis cinerea, Fusarium oxysporum, Cercospora arachidicola, Sclerotinia sclerotiorum and Physalospora piricola were tested; derivatives possessed excellent inhibitory at 50 mg L</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>It is possible that pyrazole carboxamides, which exhibit good activity against Sclerotinia sclerotiorum, can be further optimized as a lead compounds of carboxamide fungicides. © 2019 Society of Chemical Industry.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31050111</PMID>
<DateCompleted><Year>2019</Year>
<Month>12</Month>
<Day>27</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>01</Month>
<Day>08</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1526-4998</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>75</Volume>
<Issue>11</Issue>
<PubDate><Year>2019</Year>
<Month>Nov</Month>
</PubDate>
</JournalIssue>
<Title>Pest management science</Title>
<ISOAbbreviation>Pest Manag Sci</ISOAbbreviation>
</Journal>
<ArticleTitle>Novel 4-pyrazole carboxamide derivatives containing flexible chain motif: design, synthesis and antifungal activity.</ArticleTitle>
<Pagination><MedlinePgn>2892-2900</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/ps.5463</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">In recent years, carboxamide fungicides, targeting succinate dehydrogenase (SDH), have shown highly efficient and broad spectrum fungicidal activity. Structure-activity relationship (SAR) results for these commercial fungicides show that the carboxamide group was a key active group. This is useful information for the discovery of new pyrazole carboxamide derivatives with fungicidal activity.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Twenty-seven novel pyrazole carboxamides were designed and synthesized. Their fungicidal activities against Gibberella zeae, Phytophthora infestans, Phytophthora capsici, Rhizoctonia solani, Alternaria solani, Botrytis cinerea, Fusarium oxysporum, Cercospora arachidicola, Sclerotinia sclerotiorum and Physalospora piricola were tested; derivatives possessed excellent inhibitory at 50 mg L<sup>-1</sup>
 in particular. Furthermore, some pyrazole carboxamides exhibited remarkably high activities against Sclerotinia sclerotiorum in vitro with EC<sub>50</sub>
 values of 2.04 to 15.2 μg mL<sup>-1</sup>
 . In addition, some compounds also exhibited high activities against Physalospora piricola, Cercospora arachidicola and Phytophthora capsici. Inhibition activities against SDH proved that the designed analogues were effective at the enzyme level. The SAR of these pyrazole carboxamides was studied by using the docking method.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">It is possible that pyrazole carboxamides, which exhibit good activity against Sclerotinia sclerotiorum, can be further optimized as a lead compounds of carboxamide fungicides. © 2019 Society of Chemical Industry.</AbstractText>
<CopyrightInformation>© 2019 Society of Chemical Industry.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Xing-Hai</ForeName>
<Initials>XH</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0003-1464-1426</Identifier>
<AffiliationInfo><Affiliation>College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Qiao</LastName>
<ForeName>Li</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhai</LastName>
<ForeName>Zhi-Wen</ForeName>
<Initials>ZW</Initials>
<AffiliationInfo><Affiliation>College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cai</LastName>
<ForeName>Peng-Peng</ForeName>
<Initials>PP</Initials>
<AffiliationInfo><Affiliation>College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cantrell</LastName>
<ForeName>Charles L</ForeName>
<Initials>CL</Initials>
<AffiliationInfo><Affiliation>Agricultural Research Service, U.S. Department of Agriculture, Natural Products Utilization Research Unit, Oxford, MS, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tan</LastName>
<ForeName>Chen-Xia</ForeName>
<Initials>CX</Initials>
<AffiliationInfo><Affiliation>College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Weng</LastName>
<ForeName>Jian-Quan</ForeName>
<Initials>JQ</Initials>
<AffiliationInfo><Affiliation>College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Han</LastName>
<ForeName>Liang</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Hong-Ke</ForeName>
<Initials>HK</Initials>
<AffiliationInfo><Affiliation>College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, China.</Affiliation>
</AffiliationInfo>
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<ReferenceList><Title>REFERENCE</Title>
<Reference><Citation>Kramer W and Schirmer U, Modern Crop Protection. Wiley-VCH, Weinheim (2007).</Citation>
</Reference>
<Reference><Citation>Gobeil-Richard M, Tremblay DM, Beaulieu C, Van der Heyden H and Carisse O, A pyrosequencing-based method to quantify genetic substitutions associated with resistance to succinate dehydrogenase inhibitor fungicides in Botrytis spp. populations. Pest Manag Sci 72:566-573 (2016).</Citation>
</Reference>
<Reference><Citation>Hidalgo W, Cano M, Arbelaez M, Zarrazola E, Gil J, Schneider B et al., 4-Phenylphenalenones as a template for new photodynamic compounds against Mycosphaerella fijiensis. Pest Manag Sci 72:796-800 (2016).</Citation>
</Reference>
<Reference><Citation>Ren ZL, Liu H, Jiao D, Hu HT, Wang W, Gong JX et al., Design, synthesis, and antifungal activity of novel cinnamon-pyrazole carboxamide derivatives. Drug Dev Res 79:307-312 (2018).</Citation>
</Reference>
<Reference><Citation>Sun NB, Zhai ZW, Tong JY, Cai PP, He FY, Han L et al., Synthesis, crystal structure and fungicidal activity of 3-(difluoromethyl)-1-methyl-N-((2-(trifluoromethyl)phenyl)carbamoyl)-1H-pyrazole-4-caboxamide. Chin. J. Struct. Chem 38:706-712 (2019).</Citation>
</Reference>
<Reference><Citation>Yao TT, Xiao DX, Li ZS, Cheng JL, Fang SW, Du YJ et al., Design, synthesis, and fungicidal evaluation of novel pyrazole-furan and pyrazole-pyrrole carboxamide as succinate dehydrogenase inhibitors. J Agric Food Chem 65:5397-5403 (2017).</Citation>
</Reference>
<Reference><Citation>Walter H, Lamberth C and Corsi C, Synthesis of fungicidally active succinate dehydrogenase inhibitors with novel difluoromethylated heterocyclic acid moieties. Monatsh Chem 149:791-799 (2018).</Citation>
</Reference>
<Reference><Citation>Zhang AG, Zhou JY, Tao K, Hou TP and Jin H, Design, synthesis and antifungal evaluation of novel pyrazole carboxamides with diarylamines scaffold as potent succinate dehydrogenase inhibitors. Bioorg Med Chem Lett 28:3042-3045 (2018).</Citation>
</Reference>
<Reference><Citation>Zhang XX, Jin H, Deng YJ, Gao XH, Li Y, Zhao YT et al., Synthesis and biological evaluation of novel pyrazole carboxamide with diarylamine-modified scaffold as potent antifungal agents. Chin Chem Lett 28:1731-1736 (2017).</Citation>
</Reference>
<Reference><Citation>Walter H, Tobler H, Gribkov D and Corsi C, Sedaxane, isopyrazam and solatenolTM: novel broad-spectrum fungicides inhibiting succinate dehydrogenase (SDH)-synthesis challenges and biological aspects. Chimia 69:425-434 (2015).</Citation>
</Reference>
<Reference><Citation>Li SK, Li DD, Xiao TF, Zhang SS, Song ZH and Ma HY, Design, synthesis, fungicidal activity, and unexpected docking model of the first chiral Boscalid analogues containing oxazolines. J. Agric Food Chem. 64:8927-8934 (2016).</Citation>
</Reference>
<Reference><Citation>Dooley H, Shaw MW, Spink J and Kildea S, The effect of succinate dehydrogenase inhibitor/azole mixtures on selection of Zymoseptoria tritici isolates with reduced sensitivity. Pest Manag Sci 72:1150-1159 (2016).</Citation>
</Reference>
<Reference><Citation>Ye YH, Ma L, Dai ZC, Xiao Y, Zhang YY, Li DD et al., Synthesis and antifungal activity of nicotinamide derivatives as succinate dehydrogenase inhibitors. J Agric Food Chem 62:4063-4071 (2014).</Citation>
</Reference>
<Reference><Citation>Mu JX, Shi YX, Yang MY, Sun ZH, Liu XH, Li BJ et al., Design, synthesis, DFT study and antifungal activity of pyrazolecarboxamide derivatives. Molecules 21:68 (2016).</Citation>
</Reference>
<Reference><Citation>Du S, Tian Z, Yang D, Li X, Li H, Jia C et al., Synthesis, antifungal activity and structure-activity relationships of novel 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid amides. Molecules 20:8395-8408 (2015).</Citation>
</Reference>
<Reference><Citation>Liu XH, Xu XY, Tan CX, Weng JQ, Xin JH and Chen J, Synthesis crystal structure herbicidal activities and 3D-QSAR study of some novel 1,2,4-triazolo[4,3-a]pyridine derivatives. Pest Manag Sci 71:292-301 (2015).</Citation>
</Reference>
<Reference><Citation>Liu XH, Zhai ZW, Xu XY, Yang MY, Sun ZH, Weng JQ et al., Facile and efficient synthesis and herbicidal activity determination of novel 1,2,4-triazolo[4,3-a]pyridine-3(2H)-one derivatives via microwave irradiation. Bioorg Med Chem Lett 25:5524-5528 (2015).</Citation>
</Reference>
<Reference><Citation>Zhang LJ, Yang MY, Sun ZH, Tan CX, Weng JQ, Wu HK et al., Synthesis and antifungal activity of 1,3,4-thiadiazole derivatives containing pyridine group. Lett Drug Des Discov 11:1107-1111 (2014).</Citation>
</Reference>
<Reference><Citation>Liu XH, Weng JQ, Wang BL, Li YH, Tan CX and Li ZM, Microwave-assisted synthesis of novel fluorinated 1,2,4-triazole derivatives and study of their biological activity. Res Chem Intermed 40:2605-2612 (2014).</Citation>
</Reference>
<Reference><Citation>Cheng L, Cai PP, Zhang RR, Han L, Tan CX, Weng JQ et al., Synthesis and insecticidal activity of new quinoline derivatives containing perfluoropropanyl moiety. J Heterocycl Chem 56:1312-1317 (2019).</Citation>
</Reference>
<Reference><Citation>Zhai ZW, Yang MY, Sun ZH, Liu XH, Weng JQ and Tan CX, Facile and efficient synthesisof novel 1,2,3-thiadiazole derivatives using microwave irradiation. J Chem Res 39:340-342 (2015).</Citation>
</Reference>
<Reference><Citation>Zhang LJ, Yang MY, Hu BZ, Sun ZH, Liu XH, Weng JQ et al., Microwave-assisted synthesis of novel 8-chloro-[1,2,4]triazolo[4,3-a]pyridine derivatives. Turk J Chem 39:867-873 (2015).</Citation>
</Reference>
<Reference><Citation>Liu XH, Sun ZH, Yang MY, Tan CX, Weng JQ, Zhang YG et al., Microwave assistant one pot synthesis crystal structure antifungal activities and 3D-QSAR of novel 1,2,4-triazolo[4,3-a]pyridines. Chem Biol Drug Des 84:342-347 (2014).</Citation>
</Reference>
<Reference><Citation>Liu XH, Fang YM, Xie F, Zhang RR, Shen ZH, Tan CX et al., Synthesis and in vivo fungicidal activity of some new quinoline derivatives against rice blast. Pest Manag Sci 73:1900-1907 (2017).</Citation>
</Reference>
<Reference><Citation>Cheng L, Zhang RR, Wu HK, Xu TM and Liu XH, The synthesis of 6- (tert-butyl)-8-fluoro-2,3-dimethylquinoline carbonate derivatives and their antifungal activity against pyricularia oryzae. Front Chem Sci Eng 13:369-376 (2019).</Citation>
</Reference>
<Reference><Citation>Yan SL, Yang MY, Sun ZH, Min LJ, Tan CX, Weng JQ et al., Synthesis and antifungal activity of 1,2,3-thiadiazole derivatives containing 1,3,4-thiadiazole moiety. Lett Drug Des Discov 11:940-943 (2014).</Citation>
</Reference>
<Reference><Citation>Zhai ZW, Shi YX, Yang MY, Zhao W, Sun ZH, Weng JQ et al., Microwave assisted synthesis and antifungal activity of some novel thioethers containing 1,2,4-triazolo[4,3-a]pyridine moiety. Lett Drug Des Discov 13:521-525 (2016).</Citation>
</Reference>
<Reference><Citation>Liu XH, Wang Q, Sun ZH, Wedge DE, Becnel JJ, Estep AS et al., Synthesis and insecticidal activity of novel pyrimidine derivatives containing urea pharmacophore against Aedes aegypti. Pest Manag Sci 73:953-959 (2017).</Citation>
</Reference>
<Reference><Citation>Shen ZH, Sun ZH, Becnel JJ, Estep A, Wedge DE, Tan CX et al., Synthesis and mosquiticidal activity of novel hydrazone containing pyrimidine derivatives against Aedes aegypti. Lett Drug Des Discov 15:951-956 (2018).</Citation>
</Reference>
<Reference><Citation>Zhu Y, Zhao W, Han L, Dong WL and Liu XH, Synthesis and insecticidal anticancer activity of novel pyrazole acyl urea derivatives. J Chem Soc Pak 39:464-470 (2017).</Citation>
</Reference>
<Reference><Citation>Shi JJ, Ren GH, Wu NJ, Weng JQ, Xu TM, Liu XH et al., Design, synthesis and insecticidal activities of novel anthranilic diamides containing polyfluoroalkyl pyrazole moiety. Chin Chem Lett 28:1727-1730 (2017).</Citation>
</Reference>
<Reference><Citation>Sun NB, Shen ZH, Zhai ZW, Wu HK, Weng JQ, Tan CX et al., Design synthesis fungicidal activity and docking study of acyl urea derivatives containing pyrazole moiety. Chin J Org Chem 37:2044-2049 (2017).</Citation>
</Reference>
<Reference><Citation>Jin T, Zhai ZW, Han L, Weng JQ, Tan CX and Liu XH, Synthesis, crystal Structure docking and antifungal activity of a new pyrazole acylurea compound. Chin J Struct Chem 37:1259-1264 (2018).</Citation>
</Reference>
<Reference><Citation>Sun NB, Shen ZH, Zhai ZW, Han L, Weng JQ, Tan CX et al., Design synthesis fungicidal activity and docking study of acyl thiourea derivatives containing pyrazole moiety. Chin J Org Chem 37:2705-2710 (2017).</Citation>
</Reference>
<Reference><Citation>Zhao W, Shen ZH, Xu TM, Peng WL and Liu XH, Synthesis nematocidal activity and docking study of novel chiral 1-(3-chloropyridin-2-yl)-3-(difluoromethyl)-1H-pyrazole-4-carboxamide derivatives. J Heterocycl Chem 54:1751-1756 (2017).</Citation>
</Reference>
<Reference><Citation>Liu XH, Zhao W, Shen ZH, Xing JH, Yuan J, Yang G et al., Synthesis nematocidal activity and docking study of novel chiral 1-(3-chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide derivatives. Bioorg Med Chem Lett 26:3626-3628 (2016).</Citation>
</Reference>
<Reference><Citation>Zhao W, Xing JH, Xu TM, Peng WL and Liu XH, Synthesis and in vivo nematocidal evaluation of novel N-substituted 3-(trifluoromethyl)-1H-pyrazole-4-carboxamide derivatives. Front Chem Sci Eng 11:363-368 (2017).</Citation>
</Reference>
<Reference><Citation>Liu XH, Zhao W, Shen ZH, Xing JH, Xu TM and Peng WL, Synthesis nematocidal activity and SAR study of novel difluoromethylpyrazole carboxamide derivatives containing flexible alkyl chain moieties. Eur J Med Chem 125:881-889 (2017).</Citation>
</Reference>
<Reference><Citation>Zhao W, Shen ZH, Xing JH, Xu TM, Peng WL and Liu XH, Synthesis and nematocidal activity of novel pyrazole carboxamide derivatives against Meloidogyne incognita. Lett Drug Des Discov 14:323-329 (2017).</Citation>
</Reference>
<Reference><Citation>Zhao W, Shen ZH, Xing JH, Xu TM, Peng WL and Liu XH, Synthesis characterization nematocidal activity and docking study of novel pyrazole-4-carboxamide derivatives. Chin J Struct Chem 36:423-428 (2017).</Citation>
</Reference>
<Reference><Citation>Zhao W, Shen ZH, Xing JH, Yang G, Xu TM, Peng WL et al., Synthesis and nematocidal activity of novel 1-(3-chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide derivatives. Chem Pap 71:921-928 (2017).</Citation>
</Reference>
<Reference><Citation>Cheng L, Cai PP, Zhang RR, Han L, Tan CX, Weng JQ et al., Synthesis nematocidal activity and docking study of novel pyrazole-4-carboxamide derivatives against Meloidogyne incognita. Lett Drug Des Discovery 16:29-35 (2019).</Citation>
</Reference>
<Reference><Citation>Cheng L, Shen ZH, Xu TM, Tan CX, Weng JQ, Han L et al., Synthesis and nematocidal activity of N-substituted 3-methyl-1H-pyrazole-4-carboxamide derivatives against Meloidogyne incognita. J Heterocycl Chem 55:946-950 (2018).</Citation>
</Reference>
<Reference><Citation>Huang LS, Sun G, Cobessi D, Wang AC, Shen JT, Tung EY et al., 3-Nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J Biol Chem 281:5965-5972 (2016).</Citation>
</Reference>
<Reference><Citation>Lv XH, Ren ZL, Liu P, Liu BX, Li QS, Chu MJ et al., Design, synthesis and biological evaluation of novel nicotinamide derivatives bearing a substituted pyrazolemoiety as potential SDH inhibitors. Pest Manag Sci 73:1585-1592 (2017).</Citation>
</Reference>
<Reference><Citation>Wang H, Zhai ZW, Shi YX, Tan CX, Weng JQ, Han L et al., Novel trifluoromethylpyrazole acyl urea derivatives: synthesis crystal structure fungicidal activity and docking study. J Mol Struct 1171:631-638 (2018).</Citation>
</Reference>
<Reference><Citation>Wang H, Zhai ZW, Shi YX, Tan CX, Weng JQ, Han L et al., Novel trifluoromethylpyrazole acyl thiourea derivatives: synthesis antifungal activity and docking study. Lett Drug Des Discov (2019). https://doi.org/10.2174/1570180815666180704103047.</Citation>
</Reference>
</ReferenceList>
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<affiliations><list><country><li>République populaire de Chine</li>
<li>États-Unis</li>
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<region><li>Zhejiang</li>
<li>État du Mississippi</li>
</region>
<settlement><li>Hangzhou</li>
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<tree><country name="République populaire de Chine"><region name="Zhejiang"><name sortKey="Liu, Xing Hai" sort="Liu, Xing Hai" uniqKey="Liu X" first="Xing-Hai" last="Liu">Xing-Hai Liu</name>
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<name sortKey="Cai, Peng Peng" sort="Cai, Peng Peng" uniqKey="Cai P" first="Peng-Peng" last="Cai">Peng-Peng Cai</name>
<name sortKey="Han, Liang" sort="Han, Liang" uniqKey="Han L" first="Liang" last="Han">Liang Han</name>
<name sortKey="Liu, Xing Hai" sort="Liu, Xing Hai" uniqKey="Liu X" first="Xing-Hai" last="Liu">Xing-Hai Liu</name>
<name sortKey="Qiao, Li" sort="Qiao, Li" uniqKey="Qiao L" first="Li" last="Qiao">Li Qiao</name>
<name sortKey="Tan, Chen Xia" sort="Tan, Chen Xia" uniqKey="Tan C" first="Chen-Xia" last="Tan">Chen-Xia Tan</name>
<name sortKey="Weng, Jian Quan" sort="Weng, Jian Quan" uniqKey="Weng J" first="Jian-Quan" last="Weng">Jian-Quan Weng</name>
<name sortKey="Wu, Hong Ke" sort="Wu, Hong Ke" uniqKey="Wu H" first="Hong-Ke" last="Wu">Hong-Ke Wu</name>
<name sortKey="Zhai, Zhi Wen" sort="Zhai, Zhi Wen" uniqKey="Zhai Z" first="Zhi-Wen" last="Zhai">Zhi-Wen Zhai</name>
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<country name="États-Unis"><region name="État du Mississippi"><name sortKey="Cantrell, Charles L" sort="Cantrell, Charles L" uniqKey="Cantrell C" first="Charles L" last="Cantrell">Charles L. Cantrell</name>
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Novel 4-pyrazole carboxamide derivatives containing flexible chain motif: design, synthesis and antifungal activity.

Novel 4-pyrazole carboxamide derivatives containing flexible chain motif: design, synthesis and antifungal activity.

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